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Contraindicated (one)pentobarbital will lower the extent or outcome of lorlatinib by influencing hepatic/intestinal enzyme CYP3A4 metabolism.pentobarbital decreases levels of elvitegravir/cobicistat/emtricitabine/tenofovir DF by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. May possibly lead to loss of virologic response a